The compute demands of AI and robotics continue to rise due to the rapidly growing volume of data to be processed; the increasingly complex algorithms for higher quality of results; and the demands for energy efficiency and real-time performance. In this talk, we will discuss the design of efficient tailored hardware accelerators and the co-design of algorithms and hardware that reduce the energy consumption while delivering swift real-time and robust performance for applications including deep neural networks, data analytics with sparse tensor algebra, and autonomous navigation.