The automotive industry is in the midst of a significant transformation. “CASE: Connected, Autonomous, Shared & Service, Electric” has been advocated as a trend. Along with this trend, automotive E/E (Electrical/Electronic) architecture will evolve from the current distributed architecture to a domain architecture and then to the future zone architecture in the autonomous driving era. The lecture introduces the requirement of automotive system design for in-vehicle devices and their key technologies, including processors for the infotainment system and advanced vehicle control. The lecture also covers automotive functional safety.