Mammalian cells generate remarkable regulatory and functional complexity from a finite set of genes. Transcript isoform variation is a key mechanism underlying this diversity. Dr. Lin’s research harnesses the power of long-read and single-cell RNA sequencing to explore human transcriptome variations. Her lab has developed innovative platforms for RNA-based diagnostics and therapeutics of rare genetic diseases and cancer. Together, these technologies enable the systematic elucidation of transcriptomic alterations in health and disease and pave the way for RNA-based precision medicine.